Filarial antibody responses in Wuchereria bancrofti transmission area are related to parasitological but not clinical status.
Identifieur interne : 00AA14 ( Main/Exploration ); précédent : 00AA13; suivant : 00AA15Filarial antibody responses in Wuchereria bancrofti transmission area are related to parasitological but not clinical status.
Auteurs : L. Nicolas [Polynésie française] ; S. Langy ; C. Plichart ; X. DeparisSource :
- Parasite immunology [ 0141-9838 ] ; 1999.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (immunologie), Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Humains, Isotypes des immunoglobulines (immunologie), Ivermectine (usage thérapeutique), Mâle, Sujet âgé, Wuchereria bancrofti (immunologie).
- MESH :
- immunologie : Anticorps antihelminthe, Filariose lymphatique, Isotypes des immunoglobulines, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides, Ivermectine.
- Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Antibodies, Helminth (immunology), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Female, Filaricides (therapeutic use), Humans, Immunoglobulin Isotypes (immunology), Ivermectin (therapeutic use), Male, Middle Aged, Wuchereria bancrofti (immunology).
- MESH :
- chemical , immunology : Antibodies, Helminth, Immunoglobulin Isotypes.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides, Ivermectin.
- drug therapy : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adult, Aged, Animals, Female, Humans, Male, Middle Aged.
Abstract
In Wuchereria bancrofti transmission areas, three groups of individuals have been identified, according to the presence or absence of microfilariae or adult worm derived molecules in the blood compartment. These groups likely reflect individuals with different permissivity/resistance to the complete development of W. bancrofti cycle. The profile of filarial-specific immunoglobulins was analysed in W. bancrofti-exposed individuals in French Polynesia, according to the presence or absence of microfilariae (Mf) and adult worms, measured by Og4C3 circulating antigen. Individuals harbouring adult worms, have higher filarial-specific IgG4 but lower IgG3 and IgE levels, than adult worm-free individuals, independently of the presence of Mf. Low filarial-specific IgG1 and IgG2 levels were associated with the presence of Mf but independent of the presence/absence of adult worms. The filarial antibody responses were associated with the parasitological status of individuals but not with clinical symptoms such as hydroceles or limb lymphangitis or elephantiasis. The reduction of filarial-specific immunoglobulin levels was higher after treatment with diethylcarbamazine, than ivermectin, which likely reflects the better effect of the former on W. bancrofti adult worms. However, reduction of antibody levels was also observed in Mf-and adult worm-negative individuals. This could be due to the overall reduction of W. bancrofti transmission in the island where this study took place.
PubMed: 10101717
Affiliations:
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Nicolas</name><affiliation wicri:level="1"><nlm:affiliation>Institut Territorial de Recherches Médicales Louis Malardé, Papeete, Tahiti, French Polynesia.</nlm:affiliation><country xml:lang="fr">Polynésie française</country><wicri:regionArea>Institut Territorial de Recherches Médicales Louis Malardé, Papeete, Tahiti</wicri:regionArea><wicri:noRegion>Tahiti</wicri:noRegion></affiliation></author><author><name sortKey="Langy, S" sort="Langy, S" uniqKey="Langy S" first="S" last="Langy">S. Langy</name></author><author><name sortKey="Plichart, C" sort="Plichart, C" uniqKey="Plichart C" first="C" last="Plichart">C. Plichart</name></author><author><name sortKey="Deparis, X" sort="Deparis, X" uniqKey="Deparis X" first="X" last="Deparis">X. Deparis</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Antibodies, Helminth (immunology)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Filaricides (therapeutic use)</term><term>Humans</term><term>Immunoglobulin Isotypes (immunology)</term><term>Ivermectin (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Anticorps antihelminthe (immunologie)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Isotypes des immunoglobulines (immunologie)</term><term>Ivermectine (usage thérapeutique)</term><term>Mâle</term><term>Sujet âgé</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin Isotypes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Filariose lymphatique</term><term>Isotypes des immunoglobulines</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Wuchereria bancrofti transmission areas, three groups of individuals have been identified, according to the presence or absence of microfilariae or adult worm derived molecules in the blood compartment. These groups likely reflect individuals with different permissivity/resistance to the complete development of W. bancrofti cycle. The profile of filarial-specific immunoglobulins was analysed in W. bancrofti-exposed individuals in French Polynesia, according to the presence or absence of microfilariae (Mf) and adult worms, measured by Og4C3 circulating antigen. Individuals harbouring adult worms, have higher filarial-specific IgG4 but lower IgG3 and IgE levels, than adult worm-free individuals, independently of the presence of Mf. Low filarial-specific IgG1 and IgG2 levels were associated with the presence of Mf but independent of the presence/absence of adult worms. The filarial antibody responses were associated with the parasitological status of individuals but not with clinical symptoms such as hydroceles or limb lymphangitis or elephantiasis. The reduction of filarial-specific immunoglobulin levels was higher after treatment with diethylcarbamazine, than ivermectin, which likely reflects the better effect of the former on W. bancrofti adult worms. However, reduction of antibody levels was also observed in Mf-and adult worm-negative individuals. This could be due to the overall reduction of W. bancrofti transmission in the island where this study took place.</div></front></TEI><affiliations><list><country><li>Polynésie française</li></country></list><tree><noCountry><name sortKey="Deparis, X" sort="Deparis, X" uniqKey="Deparis X" first="X" last="Deparis">X. Deparis</name><name sortKey="Langy, S" sort="Langy, S" uniqKey="Langy S" first="S" last="Langy">S. Langy</name><name sortKey="Plichart, C" sort="Plichart, C" uniqKey="Plichart C" first="C" last="Plichart">C. Plichart</name></noCountry><country name="Polynésie française"><noRegion><name sortKey="Nicolas, L" sort="Nicolas, L" uniqKey="Nicolas L" first="L" last="Nicolas">L. Nicolas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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